Asthma and mycoplasma infection
Mycoplasma pneumoniae is a major pathogenic bacterium of acute pneumonia, as well as chronic infections associated with asthma and exacerbation of chronic obstructive pulmonary disease (COPD).
Bronchial asthma is a chronic bronchial inflammation caused by an allergic reaction or bacterial / viral infection, resulting in increased airway hyperresponsiveness, reversible airway narrowing, and coughing. Respiratory diseases that cause symptoms such as coughing.
Type I allergens cause seizures in atopic asthma patients, and the triggers are bacterial / viral infections, overwork, house dust (dust, mites, pollen, mold, etc.), food, drug and other allergens, exercise, tobacco, etc. There are various types such as alcohol and pressure changes.
Traditionally, when diagnosing the pathogenicity of acute pneumonia, the increase in serum antibody is highly specific and has been frequently used for the diagnosis of M. pneumoniae. A recent Asian multicenter study also showed that M. pneumoniae was involved in 12% of community-acquired pneumonia with 1,374 paired sera.
On the other hand, the actual conditions of chronic infections and subclinical infections caused by M. pneumoniae, including their diagnostic methods, are still unclear. M. pneumoniae is thought to cause superficial infections in airway epithelial cells, but in patients with asthma and COPD, it is discussed together with the intracellular parasite Chlamydia pneumoniae as a pathogenic bacterium that causes chronic infection. Is often done.
The PCR method for M. pneumoniae and C. pneumoniae, which has already been established as a diagnostic method, is that even if the airway specimens are positive for the M. pneumoniae and C. pneumoniae antigens, are there active virulence factors? It is unclear whether it is only a fragment, and in particular, in the results using materials for airway biopsy, there is no correlation between the determination by the PCR method, the culture method, and the serum antibody test method.
It has been reported that patients with asthma have a higher frequency of M. pneumoniae and C. pneumoniae infections than non-asthmatic patients, and children with infection have a higher frequency of subsequent wheezing.
Ngeow YF, et al., Int J Infect Dis 9: 144-153, 2005
Esposito S, et al., Eur Respir J 16: 1142-1146, 2000
IASR 28-2 M. pneumoniae, The Role of Mycoplasma pneumoniae Infection in Asthma
Report on the relationship between mycoplasma and asthma and the effectiveness of antibacterial treatment
Atkinson TP, Duffy LB, Pendley D, Dai Y, Cassell GH. Deficient immune response to Mycoplasma pneumoniae in childhood asthma. Allergy Asthma Proc. 30: 158-165. (2009)
Ou CY, Tseng YF, Chiou YH, Nong BR, Huang YF, Hsieh KS. The role of Mycoplasma pneumoniae in acute exacerbation of asthma in children. Acta Paediatr Taiwan. 49: 14-18. (2008)
Biscardi S, Lorrot M, Marc E, Moulin F, Boutonnat-Faucher B, Heilbronner C, Iniguez JL, Chaussain M, Nicand E, Raymond J, Gendrel D. Mycoplasma pneumoniae and asthma in children. Clin Infect Dis. 38: 1341- 1346. (2004)
Bronchiolitis, COPD, interstitial pneumonia, pulmonary fibrosis and mycoplasma infection
Interstitial pneumonia (IP) is a general term for diseases that cause inflammation, mainly in the interstitial tissue of the lungs. It is an intractable disease that is difficult to treat.
Progressive fibrosis of inflamed tissue is called pulmonary fibrosis. Of the interstitial pneumonia, idiopathic interstitial pneumonia is a specific disease in Japan. Interstitial pneumonia frequently appears as a symptomatology of fibrotic collagen diseases such as rheumatoid arthritis, systemic scleroderma, dermatomyositis, polymyositis, and MCTD. There are various causes of interstitial pneumonia, but typical ones include infection with mycoplasma and virus, complications of collagen disease, side effects of radiation gland treatment, effects of mold and asbestos, and side effects of drugs. Can be done.